Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.

نویسندگان

  • JungWha Yoon
  • HyeYoung Choi
  • Hyun Joo Lee
  • Chong Hyun Ryu
  • Hyeung-geun Park
  • Young-ger Suh
  • Uhtaek Oh
  • Yeon Su Jeong
  • Jin Kyu Choi
  • Young-Ho Park
  • Hee-Doo Kim
چکیده

A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 microM of IC(50) value in 45Ca(2+)-influx assay.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 13 9  شماره 

صفحات  -

تاریخ انتشار 2003